The basic science behind it is salt water is denser than fresh water. So, when both are present, the salt water goes to the bottom. If trout need salt water to survive (and they do), they'll most likely be found where the saltier water is.
However, as Trout Support said, it depends on where you are. If you're in an area close to where the fresh water is entering a body of water, then it's possible that entire area from top to bottom could be fresh water. Or mostly fresh water.
You just have to recognize where you are, what the fish need to survive and fish accordingly.
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